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KMID : 0043320130360060715
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Archives of Pharmacal Research
2013 Volume.36 No. 6 p.715 ~ p.722
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A new anti-inflammatory triterpene saponin isolated from Anabasis setifera
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Abdou Allia M.
Abdallah Hossam M.
Mohamed Mona A.
Fawzy Ghada A.
Abdel Naim Ashraf B.
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Abstract
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A bio-guided fractionation of Anabasis setifera Moq. (Chenopodiaceae) for anti-inflammatory activity was carried out using carrageenin rat paw edema model in rats. On the basis of percent edema inhibition after 3 h of carrageenin injection, n-butanol fraction showed promising activity through a significant (p < 0.05) decrease in paw volume by 85.6 % from control using indomethacin as reference standard. Moreover, the n-butanol fraction significantly (p < 0.05) decreased PGE2 and TNF-α in the exudates of rat paw edema. Chemical investigation of n-butanol fraction afforded α-amyrin 3-O-glucopyranoside (1), patuletin 7-O-glucopyranoside (2), myricitrin (3) and a new oleanane triterpene saponin derivative (4), sophradiol 3-O-α-l-1C4-rhamnopyranosyl-(1′′′→4′′)-O-β-d-4C1-galactopyranosyl (1′′→6′)-O-β-d-4C1-glucopyranoside. The structure of the new compound was determined by comprehensive analyses of their 1D and 2D NMR, mass spectral data and comparison with previously known analogs. Only compound 4 revealed a significant (p < 0.05) inhibition of cyclooxygenase 1 and 2 (COX) activities.
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KEYWORD
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Anabasis setifera, Sophradiol glycoside, Anti-inflammatory, Anti-COX
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